Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : c-MET inhibitor 7
Catalog No.: PC-49280Not For Human Use, Lab Use Only.
c-MET inhibitor 7 is a potent, highly selective c-MET inhibitor with IC50 of 0.90 and 0.09 μM for wild-type and D1228V c-MET, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
c-MET inhibitor 7 is a potent, highly selective c-MET inhibitor with IC50 of 0.90 and 0.09 μM for wild-type and D1228V c-MET, respectively.
c-MET inhibitor 7 binds to the hinge region via its indazole group and extending into the back pocket, with significant rearrangement of the back pocket and αC helix residues.
c-MET inhibitor 7 is highly selective, inhibit justs 3 kinases out of a panel of 140 to any significant degree (i.e. >70%).
c-MET inhibitor 7 inhibits D1228V c-MET activity in a cellular system using a homogenous time-resolved FRET target-engagement assay with IC50 of 12 uM.
| M.Wt | 460.529 | |
| Formula | C27H26F2N4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Gavin W Collie, et al. Bioorg Med Chem Lett. 2022 Aug 17;128948.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
