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Chemical Structure : dCK inhibitor DI-39
Catalog No.: PC-20182Not For Human Use, Lab Use Only.
DI-39 is a compound that inhibits the salvage pathways by blocking the enzyme, deoxycytidine kinase (dCK), induces replication stress in ALL cancer cell models through dCTP depletion.
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DI-39 is a compound that inhibits the salvage pathways by blocking the enzyme, deoxycytidine kinase (dCK), induces replication stress in ALL cancer cell models through dCTP depletion.
DI-39 selectively inhibits the salvage (NSP) pathways. shows promising activity as a single agent and more prominently as combination therapy with other inhibitors of pyrimidine de novo synthesis in ALL cancer cells and mouse models.
Simultaneous targeting of dCK with the small molecule inhibitor DI-39 and RNR with thymidine (dT) in acute lymphoblastic leukemia (ALL) cancer cells induced replication stress and apoptosis confirming synergy between de novo dCTP inhibition and pyrimidine salvage inhibition.
| M.Wt | 524.67 | |
| Formula | C21H28N6O4S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Laks DR, et al. Mol Cancer Ther. 2016 Jun;15(6):1271-8.
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