Catalog No.: PC-27186Not For Human Use, Lab Use Only.
dIRF4-2 is a first-in-class, highly seletive proteolysis-targeting chimera (PROTAC) degrader of interferon regulatory factor 4 (IRF4) with DC50 of 2.3 µM and 2.2 µM for OPM2 and MM1.S, respectively (4h).
dIRF4-2 is a first-in-class, highly seletive proteolysis-targeting chimera (PROTAC) degrader of interferon regulatory factor 4 (IRF4) with DC50 of 2.3 µM and 2.2 µM for OPM2 and MM1.S, respectively (4h).
dIRF4-2 shows rapid IRF4 depletion at 2 hours and as low as 1 µM concentrations in both MM1.S and OPM2 cell lines.
dIRF4-2 shows no neosubstrate degradation, dIRF4-2 can redirect CRBN to the nucleus to initiation degradation of IRF4, as measured by significant increases in Pearson correlation between IRF4 and CRBN.
dIRF4-2 phenocopies the effect of IRF4 loss, and is cytotoxic across IRF4-dependent MM cell models (IC50=700-800 nM).
