Catalog No.: PC-23528Not For Human Use, Lab Use Only.
iBFAR2 is a specific small molecule inhibitor of ubiquitin E3 ligase bifunctional apoptosis regulator (BFAR), inhibits USP39 ubiquitination and JAK2 deubiquitination, promoting STAT1 phosphorylation and tissue resident memory T cells (TRM) differentiation, boosts antitumor immunity in aged mice.
iBFAR2 is a specific small molecule inhibitor of ubiquitin E3 ligase bifunctional apoptosis regulator (BFAR), inhibits USP39 ubiquitination and JAK2 deubiquitination, promoting STAT1 phosphorylation and tissue resident memory T cells (TRM) differentiation, boosts antitumor immunity in aged mice.
iBFAR2 rescued the antitumor activity of aged CD8+ T cells by restoring tissue resident memory T (TRM) generation in the tumor microenvironment.
iBFAR2 efficiently inhibited tumor growth in aged CD8+ T cell transfer and anti-programmed cell death protein 1 (PD-1)-resistant mouse tumor models.
The E3 ligase BFAR suppressed cytokine-induced JAK2 signaling by activating JAK2 deubiquitination through the deubiquitinase USP39, thereby limiting downstream STAT1-mediated TRM reprogramming.
