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Chemical Structure : iHCK-37
Catalog No.: PC-72678Not For Human Use, Lab Use Only.
iHCK-37 (ASN05260065) is a potent and selective Hck inhibitor with Ki of 0.22 uM.
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iHCK-37 (ASN05260065) is a potent and selective Hck inhibitor with Ki of 0.22 uM.
iHCK-37 displays high selectivity against a panel of kinases including other Src family members (Blk, Fgr, Fyn, cSRC, Lck, Lyn, Syk, and Yes), tyrosine kinases (Abl and Abl-T315I), as well as some kinases important for HIV1 (CDK9, FAK, Itk, JAK3, Ron).
iHCK-37 has anti-neoplastic activity in leukemia cells without altering apoptosis and survival rate of normal cells.
iHCK-37 demonstrates additive effects against leukemia cells combined with 5-Azacytidine or Cytarabine, reduces the activation of oncogenic pathways, MAPK/ERK and PI3K/AKT, leading to reduction of ERK and AKT phosphorylation, and increases BAX and decreased BCL-XL protein expression.
iHCK-37 exhibits antiproliferative activity profile against the human leukemia cell line KU-812 (IC50=66.5 uM).
iHCK-37 also blocks HIV-1 replication with EC50 of 12.9 uM.
| M.Wt | 544.73 | |
| Formula | C30H32N4O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Roversi FM, et al. Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):450-461.
2. Roversi FM, et al. Cancer Immunol Immunother. 2022 Jan 18.
3. Cristina Tintori, et al. ChemMedChem. 2013 Aug;8(8):1353-60.
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