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Chemical Structure : iP300w
Catalog No.: PC-73089Not For Human Use, Lab Use Only.
iP300w (CP-C27) is a potent, selective, orally bioavailable inhibitor of p300/CBP histone acetyltransferases with IC50 of 19 nM (p300), H3K27Ac EC50 of 5 nM, does not inhibitor other HATs.
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iP300w (CP-C27) is a potent, selective, orally bioavailable inhibitor of p300/CBP histone acetyltransferases with IC50 of 19 nM (p300), H3K27Ac EC50 of 5 nM, does not inhibitor other HATs.
iP300w is a potent p300/CBP inhibitor, inhibits p300-mediated H3K9 acetylation with IC50 of 33 nM in HTRF assay.
iP300w diminishes DUX4-induced toxicity and inhibits DUX4-mediated transcription.
iP300w blocks DUX4-induced H3 acetylation and prevents the increase in expression of DUX4 target genes, erases the DUX4-mediated transcriptional fingerprint in FSHD myoblasts.
iP300w impairs DUX4-mediated transcription in vivo in the iDUX4pA FSHD mouse model.
| M.Wt | 618.565 | |
| Formula | C29H27F5N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bosnakovski D, et al. Sci Adv. 2019 Sep 11;5(9):eaaw7781.
2. Bosnakovski D, et al. Oncogenesis. 2021 Oct 12;10(10):68.
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