You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Liver X Receptor (LXR)

Request The Product List ofLiver X Receptor (LXR) Liver X Receptor (LXR)

Cat. No. Product Name Information
PC-49867

GAC0001E5

LXR inverse agonist

GAC0001E5 (LXR ligand 1E5) is a small molecule liver X receptor (LXR) inverse agonist and a potent inhibitor of pancreatic and breast cancer cells (MDA-MB-231, IC50=7.74 uM).
PC-42684

T0901317

T0901317 (TO901317) is a potent, high affinity LXR agonist (EC50=50 nM, Kd are 7 and 22 nM for LXR-α and LXR-β respectively).
PC-42687

LXR-623

LXR agonist

LXR-623 (WAY 252623) is a clinically viable, highly brain-penetrant LXRα-partial/LXRβ-full agonist with binding Ki of 33 nM/248 nM, respectively.
PC-49757

LXRβ agonist CL2-57

LXRβ agonist

LXRβ agonist CL2-57 is a non-lipogenic ABCA1 inducer and an LXRβ-selective agonist (EC50=1.3 uM) and PPAR/RXR antagonist.
PC-38644

Abequolixron

LXR agonist

RGX-104 (Abequolixron) is a small-molecule liver X receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the apolipoprotein E (ApoE) gene, enhances anti-tumor immune responses and inhibits proliferation of tumor cells.
PC-38574

GSK3987

LXR agonist

GSK3987 is a potent liver X receptor (LXR) agonist, recruits the steroid receptor coactivator-1 to human LXRα and LXRβ with EC50 of 40 nM in functional assays.
PC-63084

GSK-2033

GSK-2033 is the first potent cell-active LXR antagonist with binding pIC50 of 7.0/7.5 for LXRα/LXRβ.
PC-63083

SR-9238

SR-9238 is the first selective synthetic LXR inverse agonist that displays high potency for both LXRα and LXRβ (IC50=40-200 nM), suppresses plasma cholesterol levels in diet-induced obese mice..
PC-61598

LXRβ agonist 17

A novel, potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα.
PC-61593

BMS-852927

BMS-852927 is a highly potent liver X receptor β (LXRβ) agonist with Ki of 12 and 19 nM for LXRβ and LXRα, respectively.
PC-61220

BMS-852927

A novel potent, partial LXRβ-selective agonist (EC50=9 nM) with 20% LXRα and 88% LXRβ activity compared to a full pan agonist in transactivation assays.
PC-42686

GW3965 hydrochloride

A potent, selective, orally active LXR agonist that recruits the steroid receptor coactivator 1 to human LXRα in a cell-free ligand-sensing assay with an EC50 of 125 nM.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com