Cat. No. |
Product Name |
Information |
PC-49867 |
GAC0001E5
LXR inverse agonist
|
GAC0001E5 (LXR ligand 1E5) is a small molecule liver X receptor (LXR) inverse agonist and a potent inhibitor of pancreatic and breast cancer cells (MDA-MB-231, IC50=7.74 uM). |
PC-42684 |
T0901317
|
T0901317 (TO901317) is a potent, high affinity LXR agonist (EC50=50 nM, Kd are 7 and 22 nM for LXR-α and LXR-β respectively). |
PC-42687 |
LXR-623
LXR agonist
|
LXR-623 (WAY 252623) is a clinically viable, highly brain-penetrant LXRα-partial/LXRβ-full agonist with binding Ki of 33 nM/248 nM, respectively. |
PC-49757 |
LXRβ agonist CL2-57
LXRβ agonist
|
LXRβ agonist CL2-57 is a non-lipogenic ABCA1 inducer and an LXRβ-selective agonist (EC50=1.3 uM) and PPAR/RXR antagonist. |
PC-38644 |
Abequolixron
LXR agonist
|
RGX-104 (Abequolixron) is a small-molecule liver X receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the apolipoprotein E (ApoE) gene, enhances anti-tumor immune responses and inhibits proliferation of tumor cells. |
PC-38574 |
GSK3987
LXR agonist
|
GSK3987 is a potent liver X receptor (LXR) agonist, recruits the steroid receptor coactivator-1 to human LXRα and LXRβ with EC50 of 40 nM in functional assays. |
PC-63084 |
GSK-2033
|
GSK-2033 is the first potent cell-active LXR antagonist with binding pIC50 of 7.0/7.5 for LXRα/LXRβ. |
PC-63083 |
SR-9238
|
SR-9238 is the first selective synthetic LXR inverse agonist that displays high potency for both LXRα and LXRβ (IC50=40-200 nM), suppresses plasma cholesterol levels in diet-induced obese mice.. |
PC-61598 |
LXRβ agonist 17
|
A novel, potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα. |
PC-61593 |
BMS-852927
|
BMS-852927 is a highly potent liver X receptor β (LXRβ) agonist with Ki of 12 and 19 nM for LXRβ and LXRα, respectively. |
PC-61220 |
BMS-852927
|
A novel potent, partial LXRβ-selective agonist (EC50=9 nM) with 20% LXRα and 88% LXRβ activity compared to a full pan agonist in transactivation assays. |
PC-42686 |
GW3965 hydrochloride
|
A potent, selective, orally active LXR agonist that recruits the steroid receptor coactivator 1 to human LXRα in a cell-free ligand-sensing assay with an EC50 of 125 nM. |