Chemical Structure : (E)-Mirin
CAS No.:
299953-00-7
(E)-Mirin
Catalog No.: PC-61927Not For Human Use, Lab Use Only.
Mirin is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits MRN-mediated ATM activation (inhibition of H2AX phosphorylation) with IC50 of 66 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
(E)-Mirin is a small molecule that specifically inhibits endonuclease, but not exonuclease activity of MRE11, inhibits MRN-mediated ATM activation (inhibition of H2AX phosphorylation) with IC50 of 66 uM.
(E)-Mirin inhibits MRN/DSB-mediated ATM activation without affecting ATM protein kinase activity.
(E)-Mirin inhibits the MRN-dependent autophosphorylation of ATM at Ser1982 in response to DSBs.
(E)-Mirin inhibits dsDNA and resection in A549 cells with IC50 of 200-300 uM, abolishes the G2/M checkpoint and homology-directed DNA repair in mammalian cells.
Physicochemical Properties
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M.Wt
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220.3
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Formula
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C10H8N2O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone
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References
1. Shibata A, et al. Mol Cell. 2014 Jan 9;53(1):7-18.
2. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
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