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Chemical Structure : 2-Cl-IB-MECA
CAS No.: 163042-96-4
Catalog No.: PC-43007Not For Human Use, Lab Use Only.
2-Cl-IB-MECA (Chloro-IB-MECA, CF-102, Namodenoson) is a potent, selective A3 adenosine receptor (A3AR) agonist with Ki of 0.33 nM, 2500- and 1400-fold selectivity over A1 and A2a receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
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2-Cl-IB-MECA (Chloro-IB-MECA, CF-102, Namodenoson) is a potent, selective A3 adenosine receptor (A3AR) agonist with Ki of 0.33 nM, 2500- and 1400-fold selectivity over A1 and A2a receptors.
2-Cl-IB-MECA also displays 46,000-fold selectivity versus the Na(+)-independent adenosine transporter.
2-Cl-IB-MECA inhibits adenylate cyclase via rat A3 receptors in CHO cells (IC50=67 nM).
2-Cl-IB-MECA induces apoptosis in HL-60 cells at concentrations of <30 uM, significantly induced Ca(2+) release from intracellular Ca(2+) pools followed by Ca(2+) influx.
2-Cl-IB-MECA increases plasma histamine concentrations in conscious rats.
| M.Wt | 544.7308 | |
| Formula | C18H18ClIN6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
β-D-Ribofuranuronamide, 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl- |
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1. Van Schaick EA, et al. Eur J Pharmacol. 1996 Jul 25;308(3):311-4.
2. Kim HO, et al. J Med Chem. 1994 Oct 14;37(21):3614-21.
3. Kohno Y, et al. Biochem Biophys Res Commun. 1996 Feb 27;219(3):904-10.
4. Dunwiddie TV, et al. J Neurosci. 1997 Jan 15;17(2):607-14.
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