Catalog No.: PC-43007Not For Human Use, Lab Use Only.
2-Cl-IB-MECA (Chloro-IB-MECA, CF-102, Namodenoson) is a potent, selective A3 adenosine receptor (A3AR) agonist with Ki of 0.33 nM, 2500- and 1400-fold selectivity over A1 and A2a receptors.
2-Cl-IB-MECA (Chloro-IB-MECA, CF-102, Namodenoson) is a potent, selective A3 adenosine receptor (A3AR) agonist with Ki of 0.33 nM, 2500- and 1400-fold selectivity over A1 and A2a receptors.
2-Cl-IB-MECA also displays 46,000-fold selectivity versus the Na(+)-independent adenosine transporter.
2-Cl-IB-MECA inhibits adenylate cyclase via rat A3 receptors in CHO cells (IC50=67 nM).
2-Cl-IB-MECA induces apoptosis in HL-60 cells at concentrations of <30 uM, significantly induced Ca(2+) release from intracellular Ca(2+) pools followed by Ca(2+) influx.
2-Cl-IB-MECA increases plasma histamine concentrations in conscious rats.
