Catalog No.: PC-21903Not For Human Use, Lab Use Only.
A438079 is a selective, competitive P2X7 receptor antagonist with pIC50 of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line.
A438079 is a selective, competitive P2X7 receptor antagonist with pIC50 of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line. A438079 hows little to no activity at other P2 receptors (IC50 > 10 μM). A438079 inhibits methamphetamine-induced microglial migration and phagocytosis in vitro. A438079 possesses antinociceptive activity in models of neuropathic pain in vivo.
