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Chemical Structure : A438079
CAS No.: 899507-36-9
Catalog No.: PC-21903Not For Human Use, Lab Use Only.
A438079 is a selective, competitive P2X7 receptor antagonist with pIC50 of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | $398 | In stock | |
| 200 mg | Get quote |
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A438079 is a selective, competitive P2X7 receptor antagonist with pIC50 of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line.
A438079 hows little to no activity at other P2 receptors (IC50 > 10 μM).
A438079 inhibits methamphetamine-induced microglial migration and phagocytosis in vitro.
A438079 possesses antinociceptive activity in models of neuropathic pain in vivo.
| M.Wt | 306.15 | |
| Formula | C13H9Cl2N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]pyridine |
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1. Tsukimoto M, et al. Biochem Biophys Res Commun. 2009 Jul 10;384(4):512-8.
2. Nelson DW, et al. J Med Chem. 2006 Jun 15;49(12):3659-66. doi: 10.1021/jm051202e.
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