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AA-861

Chemical Structure : AA-861

CAS No.: 80809-81-0

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AA-861 (Docebenone)

Catalog No.: PC-62455Not For Human Use, Lab Use Only.

AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM; induces cytotoxic and anti-proliferative effects in 5-LO-positive Capan-2 pancreatic cancer cells; also efficiently inhibits biofilms by preventing the formation of amyloid-like fibers.

Allergy

Discontinued

Physicochemical Properties

M.Wt 326.436
Formula C21H26O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(12-hydroxydodeca-5,10-diynyl)- 3,5,6-trimethyl-p-benzoquinone

References

1. Romero D, et al. Chem Biol. 2013 Jan 24;20(1):102-10.

2. Yoshimoto T, et al. Biochim Biophys Acta. 1982 Nov 12;713(2):470-3.

3. Fischer AS, et al. Br J Pharmacol. 2010 Oct;161(4):936-49.

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