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Chemical Structure : AC265347
CAS No.: 1253901-26-6
Catalog No.: PC-20136Not For Human Use, Lab Use Only.
AC-265347 (AC265347) is a potent, selective CaSR agonist and positive allosteric modulator (ago-PAM), activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays with potencies of 30 and 10 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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AC-265347 (AC265347) is a potent, selective CaSR agonist and positive allosteric modulator (ago-PAM), activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays with potencies of 30 and 10 nM, respectively.
AC-265347 significantly stimulates greater responses than Cinacalcet or Calindol at each of four loss-of-function human polymorphic CaSR variants, and does not inhibit the CYP2D6 cytochrome P450 isozyme。
AC-265347 reduces serum parathyroid hormone (PTH) in rats, also reduces plasma ionizable calcium ([Ca(2+)](o)).
| M.Wt | 283.39 | |
| Formula | C17H17NOS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-Benzothiazol-2-yl-1-(2,4-dimethyl-phenyl)-ethanol |
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1. Ma JN, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):275-84.
2. Cook AE, et al. Br J Pharmacol. 2015 Jan;172(1):185-200.
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