Chemical Structure : AD-9308
CAS No.:
1804942-56-0
AD-9308
(AD9308, AD 9308)
Catalog No.: PC-21249Not For Human Use, Lab Use Only.
AD-9308 is a water-soluble, orally bioavailable, potent, and highly selective ALDH2 activator, AD-9308 is a valine ester prodrug of a potent and selective small molecule ALDH2 activator AD-5591.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AD-9308 is a water-soluble, orally bioavailable, potent, and highly selective ALDH2 activator, AD-9308 is a valine ester prodrug of a potent and selective small molecule ALDH2 activator AD-5591.
AD-5591 treatment increases the catalytic activity of recombinant wild-type and mutant human ALDH2 in vitro.
AD-9308 is rapidly converted to AD-5591 by esterase hydrolysis in vivo.
AD-9308 administration shows a favorable pharmacokinetic profile in mice when administered orally or intravenously with high bioavailability.
AD-9308 (20 mg/kg/day or 60 mg/kg/day, oral gavage for 20 weeks) lowered 4-HNE and attenuated diet-induced obesity, fatty liver, insulin resistance, and glucose intolerance in both WT and Aldh2 KI mice, ameliorated diet-induced insulin resistance and glucose intolerance.
Physicochemical Properties
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M.Wt
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537.63
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Formula
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C30H36FN3O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2-(3-((3-fluoro-4-methoxybenzyl)carbamoyl)-4-isobutoxyphenyl)pyridin-3-yl)methyl L-valinate
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References
1. Chang YC, et al. Nat Commun. 2023 Sep 25;14(1):5971.
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