Catalog No.: PC-21249Not For Human Use, Lab Use Only.
AD-9308 is a water-soluble, orally bioavailable, potent, and highly selective ALDH2 activator, AD-9308 is a valine ester prodrug of a potent and selective small molecule ALDH2 activator AD-5591.
AD-9308 is a water-soluble, orally bioavailable, potent, and highly selective ALDH2 activator, AD-9308 is a valine ester prodrug of a potent and selective small molecule ALDH2 activator AD-5591.
AD-5591 treatment increases the catalytic activity of recombinant wild-type and mutant human ALDH2 in vitro.
AD-9308 is rapidly converted to AD-5591 by esterase hydrolysis in vivo.
AD-9308 administration shows a favorable pharmacokinetic profile in mice when administered orally or intravenously with high bioavailability.
AD-9308 (20 mg/kg/day or 60 mg/kg/day, oral gavage for 20 weeks) lowered 4-HNE and attenuated diet-induced obesity, fatty liver, insulin resistance, and glucose intolerance in both WT and Aldh2 KI mice, ameliorated diet-induced insulin resistance and glucose intolerance.
