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Chemical Structure : AG 879
Catalog No.: PC-62559Not For Human Use, Lab Use Only.
Tyrphostin AG879 is a tyrphostin compound that inhibits NGF-dependent TrkA tyrosine phosphorylation in PC-12 cells with IC50 of 40 uM, also inhibits ErbB2 and VEGFR-2 (IC50=1 uM).
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Tyrphostin AG879 is a tyrphostin compound that inhibits NGF-dependent TrkA tyrosine phosphorylation in PC-12 cells with IC50 of 40 uM, also inhibits ErbB2 and VEGFR-2 (IC50=1 uM); blocks the specific interaction between the Tyr-kinase ETK and PAK1 (a CDC42/ Rac-dependent Ser/Thr kinase) in cell culture at 10 nM, suppresses the RAS-induced PAK1 activation and malignant transformation.
| M.Wt | 316.463 | |
| Formula | C18H24N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ohmichi M, et al. Biochemistry. 1993 May 4;32(17):4650-8.
2. Levitzki A, et al. Science. 1995 Mar 24;267(5205):1782-8.
3. He H, et al. Cancer Biol Ther. 2004 Jan;3(1):96-101.
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