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AM1241

Chemical Structure : AM1241

CAS No.: 444912-48-5

AM1241 (AM-1241;AM 1241)

Catalog No.: PC-60729Not For Human Use, Lab Use Only.

AM1241 is a potent, selective cannabinoid receptor CB2 agonist with Ki of 7.1 nM, >80-fold selectivity over CB1 receptors in radioligand binding assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AM1241 is a potent, selective cannabinoid receptor CB2 agonist with Ki of 7.1 nM, >80-fold selectivity over CB1 receptors in radioligand binding assay.
AM1241 suppresses spinal fos protein expression and pain behavior in a rat model of inflammation.
AM1241 dose-dependently reversed tactile and thermal hypersensitivity produced by ligation of the L5 and L6 spinal nerves in rats.

Physicochemical Properties

M.Wt 503.3
Formula C22H22IN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2-iodo-5-nitrophenyl)-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone

References

1. Malan TP Jr, et al. Pain. 2001 Sep;93(3):239-45.

2. Nackley AG, et al. Neuroscience. 2003;119(3):747-57.

3. Yao BB, et al. Br J Pharmacol. 2006 Sep;149(2):145-54.

4. Ibrahim MM, et al. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10529-33.

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