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Chemical Structure : AMG-900
CAS No.: 945595-80-2
Catalog No.: PC-43432Not For Human Use, Lab Use Only.
AMG-900 (AMG900) is a potent, highly selective, orally bioavailable pan-Aurora kinase inhibitor with IC50 of 5, 4 and 1 nM for Aurora A, B and C, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
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AMG-900 (AMG900) is a potent, highly selective, orally bioavailable pan-Aurora kinase inhibitor with IC50 of 5, 4 and 1 nM for Aurora A, B and C, respectively.
AMG-900 displays excellent specificity in a panel of 26 kinases with exception of p38α and TYK2 (IC50=53 and 220 nM), also exhibits high affinity (Kd< 50 nM) with DDR1, DDR2, and LTK receptor tyrosine kinases.
AMG-900 blocks the proliferation of multiple human tumor cell lines including cell lines resistant to paclitaxel, AZD1152, MK-0457, and PHA-739358 with IC50 of 0.7-5.3 nM.
AMG-900 blocks the phosphorylation of histone H3 in a dose-dependent manner and significantly inhibits the growth of HCT116 tumor xenografts.
| M.Wt | 503.58 | |
| Formula | C28H21N7OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Phthalazinamine, N-[4-[[3-(2-amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)- |
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1. Geuns-Meyer S, et al. J Med Chem. 2015 Jul 9;58(13):5189-207.
2. Juan G, et al. J Transl Med. 2014 Nov 4;12:307.
3. Paller CJ, et al. Cancer Med. 2014 Oct;3(5):1322-35.
4. Payton M, et al. Cancer Res. 2010 Dec 1;70(23):9846-54.
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