Catalog No.: PC-42959Not For Human Use, Lab Use Only.
Navtemadlin (AMG-232) is a potent, selective, orally bioavailable MDM2-p53 inhibitor with Kd of 0.045 nM, inhibits SJSA-1 cell proliferation with IC50 of 9.1 nM.
Navtemadlin (AMG-232) is a potent, selective, orally bioavailable MDM2-p53 inhibitor with Kd of 0.045 nM, inhibits SJSA-1 cell proliferation with IC50 of 9.1 nM.
Navtemadlin (AMG-232) robustly induces p53 activity, leading to cell-cycle arrest and inhibition of tumor cell proliferation.
Navtemadlin (AMG-232) significantly inhibits tumor growth in SJSA-1 osteosarcoma xenograft model with ED50 of 9.1 mg/kg, also showsignificantly superior antitumor efficacy chombined with chemotherapies in vivo, enhances radiosensitivity via inhibition of damage repair signaling.
