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Chemical Structure : AN1
CAS No.: 486443-73-6
Catalog No.: PC-22412Not For Human Use, Lab Use Only.
AN1 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AN1 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT.
AN1 interacts with both mHTT and LC3B but not with wtHTT or irrelevant control proteins.
AN1 significantly lowered mHTT in cortices of HD mice.
| M.Wt | 411.05 | |
| Formula | C15H9Br2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one |
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1. Li Z, et al. Nature. 2019 Nov;575(7781):203-209.
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