AN1 | mHTT degrader | Probechem Biochemicals

Chemical Structure : AN1

CAS No.: 486443-73-6

AN1 (HTT–LC3 linker AN1)

Catalog No.: PC-22412Not For Human Use, Lab Use Only.

AN1 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$148	In stock
25 mg	$258	In stock
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Biological Activity

AN1 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT.
AN1 interacts with both mHTT and LC3B but not with wtHTT or irrelevant control proteins.
AN1 significantly lowered mHTT in cortices of HD mice.

Physicochemical Properties

M.Wt	411.05
Formula	C15H9Br2NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one

References

1. Li Z, et al. Nature. 2019 Nov;575(7781):203-209.

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AN1 (HTT–LC3 linker AN1)

Biological Activity

Physicochemical Properties

References

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