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AN2

Chemical Structure : AN2

CAS No.: 7758-73-8

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AN2 (HTT–LC3 linker AN2)

Catalog No.: PC-22413Not For Human Use, Lab Use Only.

AN2 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AN2 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT.
AN2 interacts with both mHTT and LC3B but not with wtHTT or irrelevant control proteins.
AN2 significantly lowered mHTT in cortices of HD mice.

Physicochemical Properties

M.Wt 254.24
Formula C15H10O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5,7-dihydroxy-4-phenylcoumarin

References

1. Li Z, et al. Nature. 2019 Nov;575(7781):203-209.

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