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Chemical Structure : AN2
CAS No.: 7758-73-8
Catalog No.: PC-22413Not For Human Use, Lab Use Only.
AN2 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT.
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AN2 is a alkenyl oxindole molecular glue that tether mHTT to LC3, enabling the lysosomal degradation of mHTT.
AN2 interacts with both mHTT and LC3B but not with wtHTT or irrelevant control proteins.
AN2 significantly lowered mHTT in cortices of HD mice.
| M.Wt | 254.24 | |
| Formula | C15H10O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5,7-dihydroxy-4-phenylcoumarin |
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1. Li Z, et al. Nature. 2019 Nov;575(7781):203-209.
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