APX3330 (E3330) | APE1 inhibitor | Probechem Biochemicals

Chemical Structure : APX3330

CAS No.: 136164-66-4

APX3330 (E3330, APX 3330, E 3330)

Catalog No.: PC-60634Not For Human Use, Lab Use Only.

APX3330 (E3330) is a specific small-molecule inhibitor of Apurinic/apyrimidinic endonuclease 1 (APE1) redox function (IC50=50 uM), but not APE1 DNA repair activity.

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$368	In stock
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Biological Activity

APX3330 (E3330) is a specific small-molecule inhibitor of Apurinic/apyrimidinic endonuclease 1 (APE1) redox function (IC50=50 uM), but not APE1 DNA repair activity.
APX3330 (E3330) inhibits not only the growth but also the migratory abilities of pancreatic cancer cells in vitro, dramatically inhibits nuclear HIF-1α protein DNA-binding activity in PANC1 cells at >20 uM.
APX3330 (E3330) affects cytokine-mediated hemangioblast development in vitro.

Physicochemical Properties

M.Wt	378.46
Formula	C21H30O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid

References

1. Zou GM, et al. Mol Cancer Ther. 2008 Jul;7(7):2012-21.

2. Nyland RL, et al. J Med Chem. 2010 Feb 11;53(3):1200-10.

3. Curtis CD, et al. Mol Endocrinol. 2009 Sep;23(9):1346-59.

4. Zou GM, et al. Blood. 2007 Mar 1;109(5):1917-22.

APX3330 (E3330, APX 3330, E 3330)

Biological Activity

Physicochemical Properties

References

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