Chemical Structure : AR-C118925
CAS No.:
216657-60-2
AR-C118925
(AR-C 118925)
Catalog No.: PC-20993Not For Human Use, Lab Use Only.
AR-C118925 is a potent, selective, competitive P2Y2 receptor antagonist with pA2 values of 37.2 nM and 51.3 nM in calcium and β-arrestin assays, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AR-C118925 is a potent, selective, competitive P2Y2 receptor antagonist with pA2 values of 37.2 nM and 51.3 nM in calcium and β-arrestin assays, respectively.
AR-C118925 inhibits UTP-induced receptor activation with an IC50 value of 37.1 nM at the human P2Y4 receptor, at least 500-fold selective for the P2Y2 over the P2Y4 receptor.
AR-C118925 is at least 50-fold selective for the P2Y2 receptor over any other mammalian P2Y receptor subtype.
AR-C118925 is a useful pharmacological tool for in vitro as well as in vivo studies of P2Y2 receptors.
Physicochemical Properties
|
M.Wt
|
537.60
|
|
Formula
|
C28H23N7O3S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
O=C(C1=CC=C(CN(C(N2)=O)C=C(C3C4=CC=C(C)C=C4C=CC5=CC(C)=CC=C35)C2=S)O1)NC6=NN=NN6
|
References
1. Hochhauser E, et al. Purinergic Signal. 2013 Dec;9(4):633-42.
2. Rafehi M, et al. Purinergic Signal. 2017 Mar;13(1):89-103.
3. Patent WO1998054180
Contact Us
sales@probechem.com
