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Chemical Structure : AR-C118925
Catalog No.: PC-20993Not For Human Use, Lab Use Only.
AR-C118925 is a potent, selective, competitive P2Y2 receptor antagonist with pA2 values of 37.2 nM and 51.3 nM in calcium and β-arrestin assays, respectively.
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AR-C118925 is a potent, selective, competitive P2Y2 receptor antagonist with pA2 values of 37.2 nM and 51.3 nM in calcium and β-arrestin assays, respectively.
AR-C118925 inhibits UTP-induced receptor activation with an IC50 value of 37.1 nM at the human P2Y4 receptor, at least 500-fold selective for the P2Y2 over the P2Y4 receptor.
AR-C118925 is at least 50-fold selective for the P2Y2 receptor over any other mammalian P2Y receptor subtype.
AR-C118925 is a useful pharmacological tool for in vitro as well as in vivo studies of P2Y2 receptors.
| M.Wt | 537.60 | |
| Formula | C28H23N7O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hochhauser E, et al. Purinergic Signal. 2013 Dec;9(4):633-42.
2. Rafehi M, et al. Purinergic Signal. 2017 Mar;13(1):89-103.
3. Patent WO1998054180
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