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Chemical Structure : ASP 8477
Catalog No.: PC-60985Not For Human Use, Lab Use Only.
ASP8477 is a novel potent, highly selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 0.99, 1.65 and 57.3 nM for human FAAH-1, FAAH-1 (P129T) and FAAH-2, respectively.
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ASP8477 is a novel potent, highly selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 0.99, 1.65 and 57.3 nM for human FAAH-1, FAAH-1 (P129T) and FAAH-2, respectively.
ASP8477 displays no appreciable binding affinity to or inhibition against a panel of 65 receptors, ion channels and transporters, including CB1, CB2 receptors and MAGL.
ASP8477 elevates AEA concentrations in both plasma and brain in adolescent rats, significantly improves mechanical allodynia and thermal hyperalgesia in capsaicin-induced secondary hyperalgesia model (0.3-3mg/kg, p.o).
| M.Wt | 325.368 | |
| Formula | C18H19N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Watabiki T, et al. Eur J Pharmacol. 2017 Nov 15;815:42-48.
2. Bradford D, et al. Pain Med. 2017 Dec 1;18(12):2388-2400.
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