AT-9283 |CAS:896466-04-9 Probechem Biochemicals

Chemical Structure : AT-9283

CAS No.: 896466-04-9

AT-9283 (AT9283;AT 9283)

Catalog No.: PC-45829Not For Human Use, Lab Use Only.

AT-9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A, Aurora B, JAK2, JAK3, and ABL (T315I) with IC50 of 3, 3, 1.2, 1.1, and 4 nM, respectively.

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10 mg	$128	In stock
25 mg	$198	In stock
50 mg	$298	In stock
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Biological Activity

AT-9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A, Aurora B, JAK2, JAK3, and ABL (T315I) with IC50 of 3, 3, 1.2, 1.1, and 4 nM, respectively.
AT-9283 also inhibits GSK-3β, FGFR2, VEGFR3, Mer, etc. (IC50=1-10 nM).
AT-9283 potently inhibits proliferation and Jak2-related signalling in Jak2-dependent cell lines.
AT-9283 demonstrates significant therapeutic potential in vivo in an ETV6-JAK2 (TEL-JAK2) murine leukaemia model.

Physicochemical Properties

M.Wt	381.4316
Formula	C19H23N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-

References

1. Howard S, et al. J Med Chem. 2009 Jan 22;52(2):379-88.

2. Dawson MA, et al. Br J Haematol. 2010 Jul;150(1):46-57.

3. Tanaka R, et al. Blood. 2010 Sep 23;116(12):2089-95.

AT-9283 (AT9283;AT 9283)

Biological Activity

Physicochemical Properties

References

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