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Chemical Structure : AT-9283
CAS No.: 896466-04-9
Catalog No.: PC-45829Not For Human Use, Lab Use Only.
AT-9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A, Aurora B, JAK2, JAK3, and ABL (T315I) with IC50 of 3, 3, 1.2, 1.1, and 4 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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AT-9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A, Aurora B, JAK2, JAK3, and ABL (T315I) with IC50 of 3, 3, 1.2, 1.1, and 4 nM, respectively.
AT-9283 also inhibits GSK-3β, FGFR2, VEGFR3, Mer, etc. (IC50=1-10 nM).
AT-9283 potently inhibits proliferation and Jak2-related signalling in Jak2-dependent cell lines.
AT-9283 demonstrates significant therapeutic potential in vivo in an ETV6-JAK2 (TEL-JAK2) murine leukaemia model.
| M.Wt | 381.4316 | |
| Formula | C19H23N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Urea, N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]- |
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1. Howard S, et al. J Med Chem. 2009 Jan 22;52(2):379-88.
2. Dawson MA, et al. Br J Haematol. 2010 Jul;150(1):46-57.
3. Tanaka R, et al. Blood. 2010 Sep 23;116(12):2089-95.
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