Chemical Structure : ATV014
CAS No.:
2691076-98-7
ATV014
(SHEN26)
Catalog No.: PC-23359Not For Human Use, Lab Use Only.
ATV014 (SHEN26) is a potent, orally active anti-SARS-CoV-2 nucleoside compound with EC50 of 0.48 uM against SARS-CoV-2 replicon, inhibits SARS-CoV-2 RdRp.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ATV014 (SHEN26) is a potent, orally active anti-SARS-CoV-2 nucleoside compound with EC50 of 0.48 uM against SARS-CoV-2 replicon, inhibits SARS-CoV-2 RdRp.
ATV014 (SHEN26) is 3.4-fold more potent than that of GS-441524 (EC50 =1.644 μM).
ATV014 (SHEN26) shows significantly improved antiviral activities of ATV014 against B.1 (IC50 = 0.46 μM), Beta (IC50 = 0.13 μM), Delta (IC50 = 0.24 μM) and Omicron (IC50 = 0.013 μM) compared to remdesivir and GS-441524.
ATV014 (SHEN26) shows EC50 of 0.0562 uM against the B.1 strain in A549-ACE2 cells
ATV014 (SHEN26) (20, 50, 100, and 200 mg/kg) dose-dependently reduced viral RNA in the lungs.
ATV014 (SHEN26) at 200 mg/kg significantly reduced viral RNA by approximately two orders of magnitude in the Delta variant infected K18-hACE2 transgenic mice.
Physicochemical Properties
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M.Wt
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401.42
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Formula
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C19H23N5O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-cyclohexanecarboxylate
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References
1. Zhou Q, et al. Signal Transduct Target Ther. 2023 Jan 12;8(1):27.
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