AZ-31 |Cas:2088113-98-6 Buy AZ-31 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : AZ-31

AZ-31 (AZ 31;AZ31)

Catalog No.: PC-70111Not For Human Use, Lab Use Only.

A potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2 nM, cell IC50 of 46 nM.

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Biological Activity

A potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2 nM, cell IC50 of 46 nM; displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR; reduces upregulation of p21 and blocks G1 arrest in wild-type but not Cdkn1a(p21CIP/WAF1)-/- mice; showes significant tumor growth reduction in the SW620 xenograft model combined with irinotecan.

Physicochemical Properties

M.Wt	420.513
Formula	C24H28N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)quinoline-3-carboxamide

References

1. Degorce SL, et al. J Med Chem. 2016 Jul 14;59(13):6281-92.

2. Vendetti FP, et al. Sci Rep. 2017 Feb 1;7:41892.

3. Kiesel BF, et al. J Pharm Biomed Anal. 2017 May 10;138:158-165.

AZ-31 (AZ 31;AZ31)

Biological Activity

Physicochemical Properties

References

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