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Chemical Structure : AZ-31
Catalog No.: PC-70111Not For Human Use, Lab Use Only.
A potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2 nM, cell IC50 of 46 nM.
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A potent, highly selective and orally active ATM inhibitor with enzyme IC50 of <1.2 nM, cell IC50 of 46 nM; displays excellent selectivity against a panel of kinases including ATR, DNAPK, mTOR, PI3Kα, PI3Kβ, PI3Kγ, GSK3β and KDR; reduces upregulation of p21 and blocks G1 arrest in wild-type but not Cdkn1a(p21CIP/WAF1)-/- mice; showes significant tumor growth reduction in the SW620 xenograft model combined with irinotecan.
| M.Wt | 420.513 | |
| Formula | C24H28N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Degorce SL, et al. J Med Chem. 2016 Jul 14;59(13):6281-92.
2. Vendetti FP, et al. Sci Rep. 2017 Feb 1;7:41892.
3. Kiesel BF, et al. J Pharm Biomed Anal. 2017 May 10;138:158-165.
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