AZ-876 (AZ876) is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
AZ-876 is a more potent binder and activator of LXRα and LXRβ than GW3965.
AZ-876 is highly selective against FXR, RXR, TRα, TRβ etc.
AZ-876 reduces lesion area, and strongly decreases lesion area, lesion number and severity in vivo.
AZ-876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects in mice.
