Chemical Structure : AZ11645373
CAS No.:
227088-94-0
AZ11645373
(AZ 11645373)
Catalog No.: PC-22910Not For Human Use, Lab Use Only.
AZ11645373 is a selective and potent antagonist of human P2X7 receptor, inhibits ATP-mediated release of IL-1β in LPS-stimulated THP-1 monocytes with Kb of 92 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AZ11645373 is a selective and potent antagonist of human P2X7 receptor, inhibits ATP-mediated release of IL-1β in LPS-stimulated THP-1 monocytes with Kb of 92 nM.
AZ11645373 has no agonist or antagonist actions on membrane currents due to P2X receptor activation at human P2X(1), rat P2X(2), human P2X(3), rat P2X(2/3), human P2X(4), or human P2X(5) receptors expressed in HEK cells.
AZ11645373 inhibits ATP- or BzATP-evoked YO-PRO1 fluorescence in HEK cells stably expressing hP2X7R, but not rP2X7R-expressing cells.
AZ11645373 is highly effective at inhibiting ATP- and BzATP-mediated responses in all our assays on hP2X7Rs, with IC50/KB values ranging from 5 to 90 nM depending on the specific assay.
Physicochemical Properties
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M.Wt
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463.51
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Formula
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C24H21N3O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-(1-((3'-Nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione
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References
1. Laurent C, et al. Br J Pharmacol. 2006 Dec;149(7):880-7.
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