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AZD-0156

Chemical Structure : AZD-0156

CAS No.: 1821428-35-6

AZD-0156 (AZD0156;AZD 0156)

Catalog No.: PC-42030Not For Human Use, Lab Use Only.

AZD-0156 (AZD0156, AZD 0156) is a potent, highly selective and orally bioavailable ATM kinase inhibitor with IC50 of 0.58 nM.

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5 mg $78 In stock
10 mg $118 In stock
25 mg $178 In stock
50 mg $298 In stock
100 mg $488 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZD-0156 (AZD0156, AZD 0156) is a potent, highly selective and orally bioavailable ATM kinase inhibitor with IC50 of 0.58 nM.
AZD-0156 exhibits antitumoral activity, both reducing tumor burden and preventing tumors from growing in an immunocompetent allograft mouse model of AML.

Physicochemical Properties

M.Wt 461.556
Formula C26H31N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6.2 mg/mL (Need ultrasonic and warming)

Chemical Name/SMILES

2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-

References

1. Degorce SL, et al. J Med Chem. 2016 Jul 14;59(13):6281-92.

2. Morgado-Palacin I, et al. Sci Signal. 2016 Sep 13;9(445):ra91.

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