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Chemical Structure : AZD-1979
Catalog No.: PC-61510Not For Human Use, Lab Use Only.
A potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM.
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A potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM; shows no apparent affinity for MCHR2 (Ki>40 uM); dose-dependently reduces body weight in DIO mice leading to improved homeostasis model assessment-index of insulin sensitivity.
Obesity
Phase 1 Clinical
| M.Wt | 462.506 | |
| Formula | C25H26N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Johansson A, et al. J Med Chem. 2016 Mar 24;59(6):2497-511.
2. Ploj K, et al. Br J Pharmacol. 2016 Sep;173(18):2739-51.
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