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Chemical Structure : AZD-6738
CAS No.: 1352226-88-0
Catalog No.: PC-45607Not For Human Use, Lab Use Only.
AZD-6738 (AZD6738, Ceralasertib) is a potent and selective inhibitor of ATR with IC50 of 1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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AZD-6738 (AZD6738, Ceralasertib) is a potent and selective inhibitor of ATR with IC50 of 1 nM.
AZD-6738 (AZD6738, Ceralasertib) shows no significant activity for ATM, DNA-PK and mTOR.
AZD-6738 (AZD6738, Ceralasertib) inhibits ATR kinase-dependent CHK1 phosphorylation in cells (IC50=74 nM).
AZD-6738 (AZD6738, Ceralasertib) enhances the therapeutic efficacy of cisplatin in xenograft models。
AZD-6738 (AZD6738, Ceralasertib) is orally active and bioavailable.
| M.Wt | 412.5085 | |
| Formula | C20H24N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 38 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrrolo[2,3-b]pyridine, 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]- |
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1. Vendetti FP, et al. Oncotarget. 2015 Dec 29;6(42):44289-305.
2. Kwok M, et al. Blood. 2016 Feb 4;127(5):582-95.
3. Min A, et al. Mol Cancer Ther. 2017 Apr;16(4):566-577.
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