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Chemical Structure : AZD-9056
CAS No.: 345304-65-6
Catalog No.: PC-70094Not For Human Use, Lab Use Only.
AZD-9056 is a potent, selective, orally bioavailable P2X7 receptor antagonist, inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 100 mg | Get quote |
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AZD-9056 is a potent, selective, orally bioavailable P2X7 receptor antagonist, inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM.
AZD-9056 displays >100-fold selectivity and specificity other P2X receptors.
AZD-9056 also is an inhibitor of BCRP and weakly inhibited BCRP-mediated transport of methotrexate (IC50=92 uM).
AZD-9056 significantly reduces disease severity in the streptococcal cell wall (SCW) model of arthritis.
| M.Wt | 419.006 | |
| Formula | C24H35ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(adamantan-1-ylmethyl)-2-chloro-5-(3-((3-hydroxypropyl)amino)propyl)benzamide |
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1. Hu H, et al. Int J Mol Med. 2016 Dec;38(6):1922-1932.
2. Seeland S, et al. Int J Mol Med. 2016 Dec;38(6):1922-1932.
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