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Chemical Structure : AZD-9056 hydrochloride
CAS No.: 345303-91-5
Catalog No.: PC-45634Not For Human Use, Lab Use Only.
AZD-9056 hydrochloride is a potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $228 | In stock | |
| 25 mg | $388 | In stock | |
| 100 mg | Get quote |
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AZD-9056 hydrochloride is a potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM.
AZD-9056 hydrochloride displays >100-fold selectivity and specificity other P2X receptors.
AZD-9056 hydrochloride also is an inhibitor of BCRP and weakly inhibited BCRP-mediated transport of methotrexate (IC50=92 uM).
AZD-9056 hydrochloride significantly reduces disease severity in the streptococcal cell wall (SCW) model of arthritis.
| M.Wt | 455.46084 | |
| Formula | C24H36Cl2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 2-chloro-5-[3-[(3-hydroxypropyl)amino]propyl]-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-, hydrochloride (1:1) |
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1. Hu H, et al. Int J Mol Med. 2016 Dec;38(6):1922-1932.
2. Seeland S, et al. Int J Mol Med. 2016 Dec;38(6):1922-1932.
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