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Chemical Structure : AZD2066
CAS No.: 934282-55-0
Catalog No.: PC-60791Not For Human Use, Lab Use Only.
AZD2066 is a potent, selective, highly CNS-penetrant mGluR5 antagonist, inhibits Ca2+ response in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures with IC50 of 27.2, 3.56, 96.2, and 380 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $388 | In stock | |
| 10 mg | $578 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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AZD2066 is a potent, selective, highly CNS-penetrant mGluR5 antagonist, inhibits Ca2+ response in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures with IC50 of 27.2, 3.56, 96.2, and 380 nM respectively.
AZD2066 inhibits transient lower oesophageal sphincter relaxations (TLESRs) in animals and acid reflux, shows potential for treatment of gastro-oesophageal reflux.
| M.Wt | 381.82 | |
| Formula | C19H16ClN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(5-{(1R)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4H-1,2,4-triazol-3-yl)pyridine |
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1. Rohof WO, et al. Aliment Pharmacol Ther. 2012 May;35(10):1231-42.
2. Nordmark A, et al. Eur J Clin Pharmacol. 2014 Feb;70(2):167-78.
3. Swedberg MD, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):212-22.
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