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Chemical Structure : AZD628
Catalog No.: PC-73450Not For Human Use, Lab Use Only.
AZ628 (AZD-628) is a potent, selective, pan-RAF kinase inhibitor with IC50 of 105, 29 and 34 nM against for wild-type CRAF, BRAF V600E, and c-Raf-1, respectively.
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AZ628 (AZD-628) is a potent, selective, pan-RAF kinase inhibitor with IC50 of 105, 29 and 34 nM against for wild-type CRAF, BRAF V600E, and c-Raf-1, respectively.
AZ628 prevents activation of number of tyrosine protein kinases including VEGFR2, DDR2, Lyn, Flt1, FMS and others.
AZ628 suppresses anchorage-dependent and -independent growth, gives rise to cell cycle arrest, and induces apoptosis in colon and melanoma cell lines harboring B-RafV600E mutation.
AZ628 effectively suppressed p-ERK1/2 levels in the M14 parental cell line.
| M.Wt | 451.530 | |
| Formula | C27H25N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Daniel J Anderson, et al. PLoS One. 2011;6(8):e22607.
2. Vladimir Khazak, et al. Expert Opin Ther Targets. 2007 Dec;11(12):1587-609.
3. Clara Montagut, et al. Cancer Res. 2008 Jun 15;68(12):4853-61.
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