Chemical Structure : AZD 9272
Catalog No.: PC-60792Not For Human Use, Lab Use Only.
A potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM.
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A potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM; does not elicit any agonist, antagonist or positive allosteric modulator on any of the other seven mGluR subtypes at 30 uM; completely reverses the glutamate-stimulated phosphatidyl inositol hydrolysis in human mGluR5-GHEK cells with IC50 of 26 nM, causes psychoactive effects selectively mediated by mGluR5 mechanisms in vivo,
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Phase 1 Discontinued
M.Wt | 284.226 | |
Formula | C14H6F2N4O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Raboisson P, et al. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6974-9.
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