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Atopaxar hydrobromide

Chemical Structure : Atopaxar hydrobromide

CAS No.: 474550-69-1

Atopaxar hydrobromide (E5555 hydrobromide)

Catalog No.: PC-61308Not For Human Use, Lab Use Only.

Atopaxar hydrobromide (E5555) is a potent, reversible protease-activated receptor-1 (PAR-1) antagonist with IC50 of 19 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Atopaxar hydrobromide (E5555) is a potent, reversible protease-activated receptor-1 (PAR-1) antagonist with IC50 of 19 nM.
Atopaxar (E5555) shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 of 64 nM and 31 nM, respectively, with no effect on platelet aggregation induced by either ADP or collagen.
Atopaxar (E5555) inhibits arterial thrombosis without affecting bleeding time in photochemically-induced thrombosis model guinea pigs.

Physicochemical Properties

M.Wt 608.54
Formula C29H38FN3O5.HBr
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(5,6-Diethoxy-7-fluoro-1,3-dihydro-1-imino-2H-isoindol-2-yl)-1-[3-(1,1-dimethylethyl)-4-methoxy-5-(4-morpholinyl)phenyl]ethanone hydrobromide

References

1. Serebruany VL, et al. Thromb Haemost. 2009 Jul;102(1):111-9.

2. Angiolillo DJ, et al. Eur Heart J. 2010 Jan;31(1):17-28.

3. Kogushi M, et al. Eur J Pharmacol. 2011 Apr 25;657(1-3):131-7.

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