Aurora A-IN-10 |CAS:1158838-45-9 Probechem Biochemicals

Chemical Structure : Aurora A-IN-10

CAS No.: 1158838-45-9

Aurora A-IN-10

Catalog No.: PC-45948Not For Human Use, Lab Use Only.

A potent, highly selective Aurora A inhibitor with IC50 of 3.4 nM.

Packing	Price	Stock
10 mg	$104	In stock
50 mg	$328	In stock
100 mg	$588	In stock

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Biological Activity

A potent, highly selective Aurora A inhibitor with IC50 of 3.4 nM; displays >1,000-fold selectivity over Aurora B (IC50=3.4 uM) or CDKs; A useful tool compound for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B.

Physicochemical Properties

M.Wt	588.075
Formula	C31H31ClFN7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-(2-chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-

References

1. Aliagas-Martin I, et al. J Med Chem. 2009 May 28;52(10):3300-7.

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Aurora A-IN-10

Biological Activity

Physicochemical Properties

References

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