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BAY-386

Chemical Structure : BAY-386

CAS No.: 1256941-06-6

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BAY-386 (BAY386)

Catalog No.: PC-35139Not For Human Use, Lab Use Only.

BAY-386 (BAY386) is a potent, specific and reversible PAR-1 antagonist with IC50 of 10 nM (HEK cell) and binding IC50 of 56 nM, without affinity for PAR-4 (IC50>10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BAY-386 (BAY386) is a potent, specific and reversible PAR-1 antagonist with IC50 of 10 nM (HEK cell) and binding IC50 of 56 nM, without affinity for PAR-4 (IC50>10 uM).
    BAY-386 inhibits platelet aggregation with IC50 of 0.14 uM.
    BAY-386 shows potential for oral treatment of platelet-mediated thrombosis and inflammation.

    Physicochemical Properties

    M.Wt 514.52
    Formula C22H25F3N4O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ((3S,5S)-3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)(1,1-dioxidothiomorpholino)methanone

    References

    1. Christoph Gerdes, et al. Discovery and in vitro pharmacology of BAY-386-a novel, reversible PAR-1 antagonist.

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