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Chemical Structure : BAY-386
Catalog No.: PC-35139Not For Human Use, Lab Use Only.
BAY-386 (BAY386) is a potent, specific and reversible PAR-1 antagonist with IC50 of 10 nM (HEK cell) and binding IC50 of 56 nM, without affinity for PAR-4 (IC50>10 uM).
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BAY-386 (BAY386) is a potent, specific and reversible PAR-1 antagonist with IC50 of 10 nM (HEK cell) and binding IC50 of 56 nM, without affinity for PAR-4 (IC50>10 uM).
BAY-386 inhibits platelet aggregation with IC50 of 0.14 uM.
BAY-386 shows potential for oral treatment of platelet-mediated thrombosis and inflammation.
| M.Wt | 514.52 | |
| Formula | C22H25F3N4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Christoph Gerdes, et al. Discovery and in vitro pharmacology of BAY-386-a novel, reversible PAR-1 antagonist.
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