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BAY1217389

Chemical Structure : BAY1217389

CAS No.: 1554458-53-5

BAY1217389 (BAY 1217389, BAY-1217389)

Catalog No.: PC-43262Not For Human Use, Lab Use Only.

BAY1217389 (BAY-1217389) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.63 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BAY1217389 (BAY-1217389) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.63 nM.
BAY1217389 shows excellent kinase selectivity in DiscoveRx kinase panel (395 kinases), with exception of PDGFRβ (<10 nM), Kit (10-100 nM).
BAY1217389 abrogates nocodazole-induced metaphase arrest in HeLa cells with IC50 of 0.11 nM, inhibits the proliferation of a panel tumor cell lines covering various cancer with IC50 of 3-300 nM.
BAY1217389 enhances the efficacy of antimitotic cancer drugs and shows potentially overcome resistance in vivo.

Physicochemical Properties

M.Wt 561.5032
Formula C27H24F5N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 28 mg/mL

Chemical Name/SMILES

Benzamide, N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methyl-

References

1. Wengner AM, et al. Mol Cancer Ther. 2016 Apr;15(4):583-92.

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