Chemical Structure : BAY38-7271
CAS No.:
212188-60-8
BAY38-7271
(BAY 38-7271)
Catalog No.: PC-21983Not For Human Use, Lab Use Only.
BAY 38-7271 is selective, highly potent and cannabinoid CB1/CB2 receptor agonist with 0.46-1.85 nM for rat brain, human cortex, or recombinant human CB1 receptors.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BAY 38-7271 is selective, highly potent and cannabinoid CB1/CB2 receptor agonist with 0.46-1.85 nM for rat brain, human cortex, or recombinant human CB1 receptors.
BAY 38-7271 shows high affinity to cannabinoid CB2 receptors (Ki=6 nM, recombinant human cannabinoid CB2 receptor).
BAY 38-7271 induced a dose-dependent reduction in body temperature (minimal effective dose = 6 μg/kg, i.v.) in rat hypothermia assays.
BAY 38-7271 demonstrated highly potent and efficient neuroprotective properties in rat traumatic brain injury model.
BAY 38-7271 shows pronounced neuroprotective properties that do not result from drug-induced hypothermia, devoid of typical cannabinoid-like side effects.
Physicochemical Properties
|
M.Wt
|
430.44
|
|
Formula
|
C20H21F3O5S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
3-[[(2R)-2,3-Dihydro-2-(hydroxymethyl)-1H-inden-4-yl]oxy]phenyl 4,4,4-trifluoro-1-butanesulfonate
|
References
1. Mauler F, et al. BAY 38-7271: a novel highly selective and highly potent cannabinoid receptor agonist for the treatment of traumatic brain injury. CNS Drug Rev. 2003 Winter;9(4):343-58.
2. Mauler F, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):359-68.
3. De Vry J, et al. Eur J Pharmacol. 2002 Dec 20;457(2-3):147-52.
Contact Us
sales@probechem.com
