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Chemical Structure : BAY 61-3606 dihydrochloride
CAS No.: 648903-57-5
Catalog No.: PC-44143Not For Human Use, Lab Use Only.
BAY 61-3606 dihydrochloride is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase with Ki of 7.5 nM, displays no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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BAY 61-3606 dihydrochloride is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase with Ki of 7.5 nM, displays no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
BAY 61-3606 inhibits not only degranulation (IC50=5-46 nM) but also lipid mediator and cytokine synthesis in mast cells.
BAY 61-3606 suppresses B cell receptor activation and receptors for Fc portion of IgG signaling in eosinophils and monocytes.
BAY 61-3606 suppresses antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema at 3 mg/kg in rats; orally bioavailable.
| M.Wt | 463.3172 | |
| Formula | C20H20Cl2N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 4.6 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinecarboxamide, 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-, hydrochloride (1:2) |
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1. Yamamoto N, et al. J Pharmacol Exp Ther. 2003 Sep;306(3):1174-81.
2. Tabeling C, et al. Allergy. 2017 Jul;72(7):1061-1072.
3. Perova T, et al. Sci Transl Med. 2014 May 14;6(236):236ra62.
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