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Chemical Structure : BI-43
Catalog No.: PC-22469Not For Human Use, Lab Use Only.
BI-43 is a potent, selective glutaminyl cyclase inhibitor with IC50 of 12 nM and 40 nM for both sQC and gQC, respectively.
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BI-43 is a potent, selective glutaminyl cyclase inhibitor with IC50 of 12 nM and 40 nM for both sQC and gQC, respectively.
BI-43 does not show inhibition to human monozinc metalloenzyme CSN5 and dizinc metalloenzymes ecto-5′-nucleotidase (CD73) and SNM1A, as well as IDO and TDO.
BI-43 exhibits efficacy in mitigating locomotor deficits through reversing dopaminergic neuronal loss, reducing microglia, and decreasing levels of the sQC/gQC substrates, α-synuclein, and CCL2.
| M.Wt | 465.51 | |
| Formula | C27H23N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mou J, et al. J Med Chem. 2024 Jun 13;67(11):8730-8756.
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