BI-43 | Glutaminyl cyclase inhibitor | Probechem Biochemicals

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Chemical Structure : BI-43

BI-43 (Glutaminyl cyclase inhibitor BI-43)

Catalog No.: PC-22469Not For Human Use, Lab Use Only.

BI-43 is a potent, selective glutaminyl cyclase inhibitor with IC50 of 12 nM and 40 nM for both sQC and gQC, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BI-43 is a potent, selective glutaminyl cyclase inhibitor with IC50 of 12 nM and 40 nM for both sQC and gQC, respectively.
BI-43 does not show inhibition to human monozinc metalloenzyme CSN5 and dizinc metalloenzymes ecto-5′-nucleotidase (CD73) and SNM1A, as well as IDO and TDO.
BI-43 exhibits efficacy in mitigating locomotor deficits through reversing dopaminergic neuronal loss, reducing microglia, and decreasing levels of the sQC/gQC substrates, α-synuclein, and CCL2.

Physicochemical Properties

M.Wt	465.51
Formula	C27H23N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-((1H-Benzo[d]imidazol-5-yl)methylene)-4-((1-isonicotinoylpiperidin-4-yl)oxy)indolin-2-one

References

1. Mou J, et al. J Med Chem. 2024 Jun 13;67(11):8730-8756.

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BI-43 (Glutaminyl cyclase inhibitor BI-43)

Biological Activity

Physicochemical Properties

References

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