Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BIO-5192
Catalog No.: PC-61300Not For Human Use, Lab Use Only.
BIO-5192 is a potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BIO-5192 is a potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM.
BIO-5192 displays selectively over a range of other integrins (IC50 are 138, 1053, > 500 and > 10,000 nM for α9β1, α2β1, α4β7 and αIIbβ3, respectively).
BIO-5192 mobilizes hematopoietic stem and progenitor cells (HSPCs) alone or combined with plerixafor (AMD3100).
| M.Wt | 817.78 | |
| Formula | C38H46Cl2N6O8S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Leone DR, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):1150-62.
2. Theien BE, et al. Blood. 2003 Dec 15;102(13):4464-71.
3. Ramirez P, et al. Blood. 2009 Aug 13;114(7):1340-3.
4. Bao F, et al. Exp Neurol. 2008 Dec;214(2):160-7.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
