Catalog No.: PC-20741Not For Human Use, Lab Use Only.
BLU-5937 (Camlipixant, BLU5937) is a potent, selective and non-competitive P2X3 homotrimeric receptor antagonist with IC50 of 25 and 92 nM for human and rat P2X3 receptors, repsectively.
BLU-5937 (Camlipixant, BLU5937) is a potent, selective and non-competitive P2X3 homotrimeric receptor antagonist with IC50 of 25 and 92 nM for human and rat P2X3 receptors, repsectively.
BLU-5937 displays 1500-fold selectivity for human P2X3 over human P2X2/3.
BLU-5937 (500 nM) effectively inhibits P2X3-mediated sensitization of rat DRG neurons, blocks ATP-mediated neuron sensitization by inhibiting P2X3 homotrimeric receptors.
BLU-5937 (0.3-30 mg/kg, orally) reduces histamine- and ATP- induced cough hypersensitivity in guinea pigs.
BLU-5937 significantly reduced ATP- and histamineinduced enhancement in number of citric acid-induced coughs in the guinea pig.
