BMS-470539 |CAS:2341796-82-3 Probechem Biochemicals

Chemical Structure : BMS-470539

BMS-470539 (BMS 470539;BMS470539)

Catalog No.: PC-60215Not For Human Use, Lab Use Only.

BMS-470539 is a potent, selective, full agonist of human and murine melanocortin-1 receptor (MC-1R) with EC50 of 16.8 and 11.6 nM, respectively.

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Biological Activity

BMS-470539 is a potent, selective, full agonist of human and murine melanocortin-1 receptor (MC-1R) with EC50 of 16.8 and 11.6 nM, respectively.
BMS-470539 dose-dependently inhibits TNFα-induced activation of a NF-kappaB transcriptional reporter in human melanoma cells.
BMS-470539 inhibits LPS-induced TNFα production in BALB/c mice (EC50=10 uM/kg).
BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature.

Physicochemical Properties

M.Wt	632.63
Formula	C32H43Cl2N5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-N-((R)-1-(4-butyryl-4-phenylpiperidin-1-yl)-3-(4-methoxyphenyl)-1-oxopropan-2-yl)-3-(1-methyl-1H-imidazol-5-yl)propanamide dihydrochloride

References

1. Kang L, et al. J Leukoc Biol. 2006 Oct;80(4):897-904.

2. Leoni G, et al. Br J Pharmacol. 2010 May;160(1):171-80.

3. Doyle JR, et al. J Pharmacol Exp Ther. 2012 Aug;342(2):318-26.

4. Herpin TF, et al. J Med Chem. 2003 Mar 27;46(7):1123-6.

BMS-470539 (BMS 470539;BMS470539)

Biological Activity

Physicochemical Properties

References

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