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BMS 819881

Chemical Structure : BMS 819881

CAS No.: 1197420-05-5

BMS 819881 (BMS819881;BMS-819881)

Catalog No.: PC-61121Not For Human Use, Lab Use Only.

A potent, selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 10.4 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 10.4 nM; effectively blocks MCH stimulated Ca+2 mobilization in heterologous cells overexpressing MCHR1 but not the cells expressing MCHR2 at 10 uM; shows potential for treatment of obesity.

Physicochemical Properties

M.Wt 468.952
Formula C24H21ClN2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)-thieno[3,2-d]pyrimidin-4(3H)-one

References

1. Washburn WN, et al. J Med Chem. 2014 Sep 25;57(18):7509-22.

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