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BRD-7116

Chemical Structure : BRD-7116

CAS No.: 329059-55-4

BRD-7116 (BRD7116)

Catalog No.: PC-45539Not For Human Use, Lab Use Only.

A selective inhibitor of leukemia stem cells (LSCs) via inhibition of HMG-CoA reductase.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A selective inhibitor of leukemia stem cells (LSCs) via inhibition of HMG-CoA reductase; exhibits an EC50 of 200 nM for LSCe cells in co-culture; shows limited activity against normal HSPCs and AML cell lines (>10 uM).

Physicochemical Properties

M.Wt 496.6614
Formula C28H36N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 48 mg/mL

Chemical Name/SMILES

Cyclopropanecarboxamide, N,N'-(sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl- (9CI)

References

1. Hartwell KA, et al. Nat Chem Biol. 2013 Dec;9(12):840-8.

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