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Chemical Structure : Brivanib (BMS540215)
CAS No.: 649735-46-6
Catalog No.: PC-42534Not For Human Use, Lab Use Only.
Brivanib (BMS540215) is a potent, dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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Brivanib (BMS540215) is a potent, dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively.
Brivanib (BMS540215) shows weak activity for VEGFR1 (IC50=380 nM), and no significant activity on EGFR, PDGFRβ, Lck, etc.
Brivanib (BMS540215) demonstrates robust in vivo activity in human tumor xenograft models.
| M.Wt | 370.3776 | |
| Formula | C19H19FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 50 mg/mL |
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| Chemical Name/SMILES |
2-Propanol, 1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-, (2R)- |
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1. Bhide RS, et al. J Med Chem. 2006 Apr 6;49(7):2143-6.
2. Bhide RS, et al. Mol Cancer Ther. 2010 Feb;9(2):369-78.
3. Huynh H, et al. Clin Cancer Res. 2008 Oct 1;14(19):6146-53.
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