CBB1007

Chemical Structure : CBB1007

Catalog No.: PC-24000Not For Human Use, Lab Use Only.

CBB1007 is a cell-permeable, potent, reversible and substrate competitive LSD1 selective inhibitor with IC50 of 5.27 uM.

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Biological Activity

CBB1007 is a cell-permeable, potent, reversible and substrate competitive (LSD1, KDM1A) selective inhibitor with IC50 of 5.27 uM.
CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ≤ 5 μM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities.
CBB1007 induces activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ≤ 3.74 μM).
CBB1007 preferentially arrests the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cell.

Physicochemical Properties

M.Wt	534.62
Formula	C27H34N8O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 3-(4-(4-carbamimidoylbenzoyl)piperazine-1-carbonyl)-5-((4-carbamimidoylpiperazin-1-yl)methyl)benzoate

References

1. Jing Wang, et al. Cancer Res. 2011 Dec 1;71(23):7238-49.

CBB1007

Biological Activity

Physicochemical Properties

References

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