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Chemical Structure : CC-223
CAS No.: 1228013-30-6
Catalog No.: PC-45098Not For Human Use, Lab Use Only.
CC-223 is a potent, selective, and orally bioavailable inhibitor of mTOR kinase with IC50 of 16 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 100 mg | $658 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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CC-223 is a potent, selective, and orally bioavailable inhibitor of mTOR kinase with IC50 of 16 nM.
CC-223 displays >200-fold selectivity over the related PI3K-α (IC50=4.0 uM), shows no significant inhibition of ATR or SMG1 and weakly inhibits DNA-PK (IC50=0.84 uM).
CC-223 inhibits mTORC1 (pS6RP and p4EBP1) and mTORC2 [pAKT(S473)] in cellular systems, exhibits growth inhibitory activity in hematologic and solid tumor cell lines.
CC-223 demonstrates tumor growth inhibition in multiple solid tumor xenografts.
| M.Wt | 397.4708 | |
| Formula | C21H27N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 27 mg/mL |
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| Chemical Name/SMILES |
Pyrazino[2,3-b]pyrazin-2(1H)-one, 3,4-dihydro-7-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-(trans-4-methoxycyclohexyl)- |
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1. Mortensen DS, et al. J Med Chem. 2015 Jul 9;58(13):5323-33.
2. Mortensen DS, et al. Mol Cancer Ther. 2015 Jun;14(6):1295-305.
3. Bendell JC, et al. Cancer. 2015 Oct 1;121(19):3481-90.
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